PML/RARA gene fusion probe29

Product Name:PML/RARA gene fusion probe Product Description: PML/RARA gene fusion probe uses the PML probe labeled with orange red dye and the RARA probe labeled with green dye, the two probes can be combined with the target detection site by in situ hybridization. Normally (PML / RARA gene did not fuse), two orange and two green signals were displayed under fluorescence microscopy. When fusion genes exist, green and orange signals are reconstituted to form yellow fusion signals.PML/RARA fusion gene is a characteristic marker of acute promyelocytic leukemia (APL). PML / RARA fusion proteins inhibit the differentiation and maturation of promyelocytes through dominant negative inhibition, thereby blocking cell differentiation and leading to sustained proliferation. All trans retinoic acid (ATRA) and arsenic trioxide can degrade PML/RARA fusion protein, restore the function of wild type PML and RARA gene, relieve the inhibition of gene transcription, induce cell differentiation and apoptosis, so that APL can be effectively treated. The combined use of ATRA and chemotherapy can achieve a complete remission rate of APL for 90%~95%, More than 70% of the patients can survive for a long time. Price:30.00 Product Website:https://www.health-carebiotech.com/molecular-diagnostic-probe/fluorescence-in-situ-hybridization-probes/pml-rara-fusion-probe.html Company Description Wuhan Healthcare Biotechnology co.,Ltd Address:HubeiHubeiWuhanDonghuNO666,Gaoxin Boulevard ,Optics Valley Biolake,Building B6 Descption:HealthCare Biotech is a molecular diagnostics manufacturer of Fluorescence in-situ hybridization (FISH) probes for cancer and hematology , Real-Time PCR kits and Automation for use in medical research and diagnostics. Registered Capital:860 EmployeeNum:100 Wuhan Healthcare Biotechnology co.,Ltd Contact:Nyobe Lambert Telphone:86-027-65022930-0 Fax:86-027-87850869-0 Email:[email protected] Company Website:http://www.health-carebiotech.com