TOP2A Amplification Probe29

Product Name:TOP2A Amplification Probe Product Description: TOP2A Gene Amplification Detection ProbeProduct Advantages: ?1.Fleetness: Tissue probe hybridization time: 2 hours. Cell probe hybridization time: 1 hour.?2.Accuracy: Less non-specific background staining (dyeing). Increase difficult samples detection rate.?3.Reproducibility: Different laboratories test results are highly reproducible.??About TOP2A The TOP2A gene encodes DNA topoisomerase. This enzyme is involved in processes such as chromosome condensation, chromatid separation, and the release of torsional stress that occurs during DNA transcription and replication. The gene encoding this form, TOP2α, is located on chromosome 17, and the β gene is located on chromosome 3. Many mutations in this gene are associated with developmental resistance.?Probe DescriptionThe TOP2A gene amplification probe is labeled with orange dye for TOP2A gene region, and green dye for chromosome 17 centromere region (CEP17). The TOP2A gene tagged region is located at 17q21.2. The CEP17 probe adopts the α-satellite sequence and has a very high specificity. It does not generate hybrids with other chromosome centromeres.?Clinical SignificancePatients with abnormal TOP2A genes are predictive of a shorter relapse-free survival, and patients with TOP2A gene deletion have worse prognosis. The study of advanced breast cancer found that TOP2A gene anomalies are significantly associated with protein expression and tumor cell sensitivity to anthracyclines. Therefore, the detection of TOP2A gene status has guiding significance for the treatment and prognosis of breast cancer.?Size Specifications?Reference Brunello E,et al.(2012) Histopathology 60: 482-8.Razis E,et al.(2011) Breast Cancer Res Treat 128: 447-56. Price:30.00 Product Website:http://www.health-carebiotech.com/molecular-diagnostic-probe/fluorescence-in-situ-hybridization-probes/top2a-amplification-probe.html Company Description Wuhan Healthcare Biotechnology co.,Ltd Address:HubeiHubeiWuhanDonghuNO666,Gaoxin Boulevard ,Optics Valley Biolake,Building B6 Descption:HealthCare Biotech is a molecular diagnostics manufacturer of Fluorescence in-situ hybridization (FISH) probes for cancer and hematology , Real-Time PCR kits and Automation for use in medical research and diagnostics. Registered Capital:860 EmployeeNum:100 Wuhan Healthcare Biotechnology co.,Ltd Contact:Nyobe Lambert Telphone:86-027-65022930-0 Fax:86-027-87850869-0 Email:[email protected] Company Website:http://www.health-carebiotech.com