Indometacin 53-86-1 [email protected]

Product Description 0.jpg Specifciation: 1.Competitive price 2.Fast Delivery Within 2 days 3.SGS , BV, GMP,ISO approve 4.Professional factory QQ20180531101300.png Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. Other studies show indomethacin to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes, which could consequentially effect plasma membrane assembled cell signaling cascades. Indomethacin is an activator of PPAR α. Functions 10.jpg Indometacin (INN and BAN) or indomethacin (AAN, USAN and former BAN) is a non-steroidal anti-inflammatory drug(NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling. It works by inhibiting the production of prostaglandins, molecules known to cause these symptoms. It is marketed under more than twelve different trade names. Clinical indications for indometacin include: ankylosing spondylitis arthritic gout Bartter syndrome bursitis cryoglobulinemia dysmenorrhea (menstrual cramps) fever and pain associated with malignant diseases (especially tumor fever associated with liver involvement, lymphogranulomatosis) headaches caused by the Valsalva maneuver hemicrania continua hypnic headache juvenile arthritis migraine nephrogenic diabetes insipidus (prostaglandin inhibits vasopressin's action in the kidney) osteoarthritis Paget's disease of bone paroxysmal hemicrania patent ductus arteriosus pericarditis primary exertion headache primary stabbing headaches pseudogout psoriatic arthritis reactive arthritis renal colic (pain due to kidney stones) retinopathy of prematurity rheumatoid arthritis tendinitis trigeminal autonomic cephalgias Indometacin has also been used clinically to delay premature labor, reduce amniotic fluid in polyhydramnios, and to close patent ductus arteriosus. Indometacin is a potent drug with many serious side effects and should not be considered an analgesic for minor aches and pains or fever. The medication is better described as an anti-inflammatory, rather than an analgesic. Indometacin can also affect warfarin and subsequently raise INR. Analysis 5.jpg Product Name Indomethacin MFG. Date Dec.12.2015 Batch NO. HS13-068 EXP. Date Dec.11.2018 Batch quantity 300kg Analysis Date Dec.18.2015 Standard BP2005 Items Specification Results Characters White crystalline powder ,parctically insoluble in water, sparingly soluble in alcohol Conforms Identification A.Melting point 158-162°C 158.5-160.0°C B.Absorption at 318nm 170-190 185.19 C. Conforms to the requirement Conforms D. Conforms to the requirement Conforms E. Conforms to the requirement Conforms Related substances(TLC) Not more than 0.5% <0.5% Heavy metals Not more than 20ppm <20ppm Loss on drying Not more than 0.5% 0.13% Sulphated Ash Not more than 0.1% 0.07% Assay 98.5%-100.5% 99.8% Conclusion:Complies with EP7 Real Shot 4.jpg Indometacin (48).png