Coluracetam

Classification:OtherChemicals CasNO.:135463-81-9 MolecularFormula:C19H23N3O3 MeltingPoint: BoilingPoint:634.1°Cat760mmHg Stability:null Refractiveindex:1.64 FlashPoint:337.3°C Purity:99 Appearance:null usage:anootropicdrugoftheracetamfamily BrandName:myland EINECS:1308068-626-2 Aliase:N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide. Purity:99 Appearance:whitecrystallinepowder Brand:myland Packaging&Delivery PackagingDetail:1kg/bag. DeliveryDetail: DetailedDescription Productname:Coluracetam Chemicalname:N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide. CAS:135463-81-9 Purity:99% Appearance:whitecrystallinepowder Package:1kg/bag. Coluracetam(BCI-540)isanootropicdrugoftheracetamfamily.Coluracetam(formerlyknownasMKC-231)wasinitiallydevelopedandtestedbytheMitsubishiTanabePharmaCorporationforAlzheimer'sdisease.Afterthedrugfailedtoreachendpointsinitsclinicaltrialsitwasin-licensedbyBrainCellsIncforinvestigationsintomajordepressiondisorder(MDD),afterbeingawardeda"QualifyingTherapeuticDiscoveryProgramGrant"bythestateofCalifornia.FindingsfromitsPhase2aclinicaltrialshavesuggestedthatitwouldbeanidealmedicationforco-morbidMDDwithgeneralizedanxietydisorder(GAD).BrainCellsInciscurrentlyout-licensingthedrugforthispurpose.Itmayalsohavepotentialuseinpreventionandtreatmentofischemicretinopathyandretinalandopticnerveinjury. Coluracetamenhanceshigh-affinitycholineuptake(HACU)whichistherate-limitingstepofacetylcholine(ACh)synthesis,andistheonlyknowncholineuptakeenhancertocurrentlyexist.StudieshaveshownColuracetamtoimprovelearningimpairmentonasingleoraldosegiventoratswhichhavebeenexposedtocholinergicneurotoxins.Subsequentstudieshaveshownthatitmayinducelong-lastingprocognitiveeffectsbychangingthecholinetransporterregulationsystem.