Recombinant Human LDLR Protein(His tag)

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins (PubMed:10535997, PubMed:12615904). Acts as a receptor for vesicular stomatitis virus (PubMed:23589850). In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells (PubMed:11100124). Recombinant Human LDLR Protein (P01130) (Ala 22 - Arg 788) with a polyhistidine tag at the C-terminus was expressed in HEK293. https://www.profacgen.com/rhuman-ldlr-his-tag-1339.htm