Recombinant Human TNFRSF18 Protein (hIgG-His tag)

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Recombinant Human TNFRSF18 Protein (NP_004186) (26-162aa) with C-terminus hIgG-His tag was expressed in Insect cells. https://www.profacgen.com/rhutnfrsf18-his-tag-1219.htm